Intravenous Thrombolysis Is Associated With Better Outcomes in Large‐Vessel Occlusion Requiring Endovascular Therapy

Background Intravenous thrombolysis (IVT) and endovascular therapy (EVT) are both important treatments for large‐vessel occlusion stroke. However, it is still unclear how the timing of IVT, EVT, need transfer a patient to an stroke center EVT affect outcomes. In this investigation, we study interaction between rapidity among patients with Methods This investigation analysis OPUS‐REACH (Optimizing Use Prehospital Stroke Systems Care–Reacting Changing Paradigms) registry from 9 centers in United States. Using database, extracted baseline characteristics patients, whether received time intervals patients’ care. Patient demographics were compared 2 groups using χ test categorical variables 2‐sample t ‐tests or Wilcoxon rank‐sum tests continuous variables. Multivariable logistic regression was performed determine adjusted associations 90‐day dichotomized modified Rankin Scale outcome. Results A total 1171 included final analysis, 38.9% had good functional outcome at 90 days. Male sex lower initial National Institutes Health score nonmodifiable factors associated clinical We saw no differences underwent primary secondary transport. On multiple variable receipt IVT only modifiable factor found overall effect last known well on outcomes unless IVT. Conclusions independently improved days odds ratio 1.51. Neither shorter nor direct transport versus therefore conclude that prehospital algorithms must account timely administration over EVT.